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Late complications include amyloidosis and malignant neoplasms in the bladder or large intestine.
Adult worm gut antigen–antibody complex-mediated lesions may lead to several forms of glomerulonephritis.
Patients experiencing persistent somnolence may benefit from administering half the daily dose twice daily.
2 mg per day to 8 mg per day at delaying relapse was demonstrated in a controlled trial in adult patients who had been clinically stable for at least 4 weeks and were then followed for a period of 1 to 2 years .
The effective dose range is 1 mg to 6 mg per day, as studied in the short-term, placebo-controlled trials.
Active schistosomal lesions are treated with praziquantel or artemether with variable species-related outcomes.The safety of doses above 16 mg per day has not been evaluated in clinical trials The initial dose is 0.5 mg once daily, administered as a single-daily dose in the morning or evening.The dose may be adjusted at intervals of 24 hours or greater, in increments of 0.5 mg or 1 mg per day, as tolerated, to a recommended dose of 3 mg per day.Efficacy was established in one short-term trial in adults is indicated for the treatment of irritability associated with autistic disorder, including symptoms of aggression towards others, deliberate self-injuriousness, temper tantrums, and quickly changing moods.Efficacy was established in 3 short-term trials in children and adolescents (ages 5 to 17 years) can be administered once or twice daily. May increase the dose at intervals of 24 hours or greater, in increments of 1 to 2 mg per day, as tolerated, to a recommended dose of 4 to 8 mg per day.